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Antifungal susceptibility testing of clinical isolates of itraconazole-resistant Aspergillus fumigatus to four antifungal drugs
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:0412-4030.2007.12.003
- Key Word:
- 曲霉菌,烟;伊曲康唑;抗药性,真菌
Abstract： 目的 测定耐伊曲康唑烟曲霉临床株对4种抗真菌药物的敏感性.方法 自一例对伊曲康唑无效的肺曲霉球患者体内系列分离6株烟曲霉.利用美国临床实验室标准化研究所(CLSI)的微量液基稀释法M38-A方案和E-test法测定6株烟曲霉临床分离株对两性霉素B、卡泊芬净、米卡芬净、伏立康唑和伊曲康唑的敏感性.结果 6株烟曲霉中,2株对伊曲康唑的最低抑菌浓度(MIC)为0.5 μg/mL,其他4株的MIC均＞16 μg/mL;两性霉素B和伏立康唑对6株烟曲霉的MIC分别为1μg/mL和0.25～1 μg/mL,卡泊芬净和米卡芬净对6株烟曲霉的最低有效浓度均≤0.03μg/mL.E-test法测定结果也显示,卡泊芬净和伏立康唑对6株烟曲霉有良好的抑制活性.结论 耐伊曲康唑烟曲霉临床株对两性霉素B、卡泊芬净、米卡芬净和伏立康唑敏感.
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