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A case of Langerhans cell histiocytosis in a 76-year-old woman
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 10
- DOI:
- 10.3760/j.issn:0412-4030.2007.10.004
- Key Word:
- 组织细胞增多症;郎格汉斯细胞;老年人
Abstract： 76岁女性患者,外阴部溃疡伴突眼5年,双侧乳房下红斑糜烂半年,尿崩症3个月.皮损为红斑、丘疹,部分表面有褐红色痂,主要位于双侧乳房下皱襞处、双腋窝及腰部.皮损组织病理检查显示真皮浅层局限性胞质丰富的大细胞和淋巴样细胞浸润,并见部分大细胞移入表皮或毛囊上皮,细胞核大深染,有异形性,核周有空晕,免疫组化显示这些大细胞S100、CD1a阳性,CD68阴性.根据患者的临床表现、组织病理和免疫组化结果,确诊为慢性多灶性朗格汉斯细胞增生症.
- [1]周晓冬,宋国祥,何彦津.眼眶组织细胞增生症X临床分析[J].2003,(11).
- [2]R B, Islinger,T R, Kuklo,B D, Owens,etc.Langerhans' cell histiocytosis in patients older than 21 years.[J].2000,(379).
- [3]T, Nakajima,S, Watanabe,Y, Sato,etc.S-100 protein in Langerhans cells, interdigitating reticulum cells and histiocytosis X cells.[J].1982,73(3).
- [4]R A, Grimm,H B, Muss,R B, Patterson,etc.Reactivation of Hand-Schüller-Christian disease six and thirteen years after discontinuation of systemic therapy.[J].1981,9(1).
- [5]V. Conter,M. L. Rabbone,M. Jankovic,etc.Overdose of Vinblastine in a Child with Langerhans' Cell Histiocytosis: Toxicity and Salvage Therapy[J].1991,8(2).
- [6]F, Laczi,L, Czako,F A, László.Experience of prolonged treatment of hand-Schüller-Christian disease with prednisolone.[J].1977,70(3).