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Detection of serum leptin, soluble leptin receptor and insulin in patients with benign acanthosis nigricans
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:0412-4030.2007.07.002
- Key Word:
- 棘皮症,黑;胰岛素;瘦素
Abstract： 目的 探讨假性黑棘皮病患者血清瘦素及其受体与胰岛素之间的关系.方法 分别采用放射免疫分析法、酶联免疫吸附实验和葡萄糖氧化酶法检测25例假性黑棘皮病、20例单纯肥胖者瘦素、胰岛素、C肽可溶性受体与血糖水平,并与正常人对照组比较.结果 假性黑棘皮病患者和单纯肥胖者体质量、体质指数、脂肪百分比、腰臀围比明显高于正常人对照组,两组差异有统计学意义(P＜0.01).假性黑棘皮病患者和单纯肥胖者胰岛素、C肽水平明显高于正常人对照组(P＜0.01),胰岛素敏感指数低于正常人对照组(P＜0.01);单纯肥胖者血糖水平和正常人对照组相比,差异无统计学意义(P＞0.05);假性黑棘皮病患者与单纯肥胖者血清中瘦素水平和正常人对照组相比显著升高(P＜0.01),可溶性瘦素受体水平显著降低(P＜0.01).结论 假性黑棘皮病患者存在瘦素抵抗、高胰岛素血症和胰岛素抵抗,瘦素抵抗在假性黑棘皮病患者高胰岛素血症、胰岛素抵抗与肥胖中起一定的作用.
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