You Position: Home > Paper
Correlation of disease severity with serum titer of anti-BP180 autoantibody in patients with bullous pemphigoid
( views:522, downloads:146 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:0412-4030.2007.04.003
- Key Word:
- 类天疱疮,大疱性;自身抗体;BP180;疾病严重程度
Abstract： 目的 研究大疱性类天疱疮患者临床疾病严重程度和BP180抗体滴度之间的关系.方法 用BP180NC16a-ELISA分别测定大疱性类天疱疮患者治疗前,病情缓解、糖皮质激素开始减量时和糖皮质激素减量至相当于泼尼松0.5 mg·kg-1·d-1时,体内BP180抗体滴度,观察其与患者病情严重程度的一致性.结果 在治疗前,19例大疱性类天疱疮患者的BP180 ELISA平均A值为0.520(0.832～0.372);在病情得到控制、糖皮质激素准备减量时,其BP180 ELISA平均A值为0.405(O.723～0.204);在病情缓解、糖皮质激素减至相当于泼尼松0.5 mg·kg-1·d-1时,其BP180 ELISA平均A值为0.215(0.412～0.093).结论 BP180抗体的滴度与大疱性类天疱疮患者疾病严重程度相关,是一种评估疾病病情的有用手段,也可对治疗的有效性作出评价.
- [1]冯素英,吴勤学,林麟,等.BP180NC16a-ELISA对大疱性类天疱疮血清学诊断的评价[J].2007,(1).
- [2]Nakatani,C,Muramatsu,T,Shirai,T.Immunoreactivity of bullous pemphigoid (BP) autoantibodies against the NC16A and C-terminal domains of the 180 kDa BP antigen (BP180): immunoblot analysis and enzyme-linked immunosorbent assay using BP180 recombinant proteins.[J].1998,139(3).
- [3]E, Schmidt,K, Obe,E B, Br?cker,etc.Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid.[J].2000,136(2).
- [4]G J, Giudice,K C, Wilske,G J, Anhalt,etc.Development of an ELISA to detect anti-BP180 autoantibodies in bullous pemphigoid and herpes gestationis.[J].1994,102(6).
- [5]Kikuchi T,Sato Matsumura KC,Tsuji Abe Y,etc.Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid.[J].2005,37(3).
- [6]Yasuyuki Amo,Tsukasa Ohkawa,Minako Tatsuta,etc.Clinical significance of enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid[J].2001,26(1).
- [7]G J, Giudice,D J, Emery,B D, Zelickson,etc.Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain.[J].1993,151(10).