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Stevens-Johnson syndrome without skin lesions:a report of 4 cases
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:0412-4030.2007.04.002
- Key Word:
- Stevens-Johnson综合征;支原体,肺炎;柯萨奇病毒感染
Abstract： 目的 报道4例无皮疹型Stevens-Johnson综合征,并对该病有关文献进行综述.方法 对4例患者的发病因素、临床特征及治疗进行较为系统地观察.结果 4例均为儿童,表现有发热,口唇黏膜肿胀、糜烂、出血性渗出和坏死,3例有结膜炎症,其中2例出现睑结膜纤维素样渗出;4例都无明显皮肤损害.3例进行了肺炎支原体抗体和冷凝集试验检测,肺炎支原体抗体IgG全部阳性,冷凝集试验仅1例阳性,为1:128(正常低于1:32).2例入院前诊断"化脓性扁桃体炎",其中1例发疹时抗链球菌溶血素O试验1240 Iu/mL阳性(正常低于200 IU/mL).2例柯萨奇病毒IgM检测阳性.单用抗生素治疗无效,对糖皮质激素治疗敏感,4例均痊愈.结论 无皮疹型Stevens-Johnson综合征的预后较好,其病因仍以感染为主,尤其是肺炎支原体、病毒感染更应加以重视.
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