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Down-regulation of TGF β receptor expression in human basal cell carcinoma and squamous cell carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:0412-4030.2006.11.001
- Key Word:
- 癌,基底细胞;癌,鳞状细胞;转化生长因子β;受体,转化生长因子β
Abstract： 目的 探讨转化生长因子β(TGFβ)受体在基底细胞癌和鳞状细胞癌中表达水平的变化及其意义.方法 采用实时定量PCR和SP免疫组化技术分别检测基底细胞癌、鳞状细胞癌及正常人对照皮肤中Ⅰ型和Ⅱ型TGFβ受体(TGFβR Ⅰ,TGFβRⅡ)mRNA和蛋白的表达.结果 对18例基底细胞癌、24例鳞状细胞癌患者的皮损及正常人对照皮肤的研究显示,基底细胞癌和鳞状细胞癌皮损TGFβR Ⅰ和TGFβRⅡ的mRNA表达水平均显著低于正常人对照皮肤.免疫组化试验结果显示:TGFβR Ⅰ染色强度在基底细胞癌组、鳞状细胞癌组较正常人对照皮肤组显著降低(P＜0.001);TGfβRⅡ在二组表皮肿瘤与正常人对照皮肤组间表达差异也有统计学意义(P＜0.01).结论 基底细胞癌和鳞状细胞癌中TGFβ受体表达下调可能有助于这些上皮细胞起源的表皮肿瘤的形成.
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