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The -109 polymorphism at the promoter region of high-affinity IgE receptor β gene in patients with atopic dermatitis in Han nationality in Hunan Province
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:0412-4030.2006.09.004
- Key Word:
- 皮炎,特应性;受体,IgE;多态性,单核苷酸;突变;免疫球蛋白E
Abstract： 目的 探讨湘籍汉族特应性皮炎患者IgE高亲和力受体β链(FcεRIβ)基因启动子-109位基因多态性及与血清总IgE的关系.方法 采用PCR-单链构型多态性(SSCP),DNA测序分析FcεRIβ基因多态性,ELISA检测血清总IgE.结果 20例特应性皮炎患者中有4例FcεRIβ基因启动子-109位泳动异常,其中有2例特应性皮炎患者第138位碱基发生C→A替换,159位碱基发生T→C替换;2例患者165位碱基发生A→G替换.突变组特应性皮炎患者血清总的IgE为(1.88±1.30)mg/L,无突变组特应性皮炎患者血清总的IgE为(0.32±0.12)mg/L,正常人对照组血清总的IgE为(0.20±0.05)mg/L;突变组较无突变组及正常人对照组差异有统计学意义(P＜0.05).结论 特应性皮炎患者IgE高亲和力受体β链启动区-109位多态性伴有IgE高表达.
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