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Recognition of vitiligo associated protein VIT-1 gene and its sequence analysis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:0412-4030.2006.04.004
- Key Word:
- 白癜风;黑素细胞;F框蛋白质类;FBXO11;白癜风相关基因-1
Abstract： 目的探讨白癜风患者黑素细胞VIT-1基因转录水平的表达情况,分析该基因序列的差异性.方法用半定量RT-PCR法检测黑素细胞VIT-1基因表达水平,克隆VIT-1 ORF cDNA全长并测序,序列差异由CLUSTAL W(1.83)软件分析.结果黑素细胞的VIT-1基因ORF含有81 bp的内含子,为FBXO11的3′端的部分序列,白癜风患者黑素细胞VIT-1基因表达量下降.结论VIT-1不是一个新基因,而是FBXO11,属于F-box蛋白家族成员.
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