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The methylation of p16 promotor in psoriatic keratinocytes

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DERMATOLOGY
Issue:
3
DOI:
10.3760/j.issn:0412-4030.2006.03.003
Key Word:
银屑病;基因,p16;甲基化;启动区(遗传学)

Abstract: 目的探讨p16启动子甲基化与银屑病发生发展的关系.方法采用甲基化特异性PCR及基因测序技术检测p16启动子.结果26例银屑病患者皮损和非皮损甲基化率分别为23.08%(6/26)和19.23%(5/26),明显高于正常对照(P<0.05);12例进行期皮损和非皮损p16启动子甲基化率均为41.67%(5/12),14例静止期分别为7.14%(1/14)和0,进行期甲基化率明显高于静止期(P<0.05).结论p16启动子甲基化与银屑病的发生发展相关,且与病期相关.

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