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Expression of β-Catenin and LEF-1 in Malignant Melanoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:0412-4030.2005.11.003
- Key Word:
- 黑色素瘤;β联蛋白;淋巴样增强因子1
Abstract： 目的探讨β联蛋白、淋巴样增强因子1在恶性黑素瘤中的表达及意义.方法采用免疫组化PowerVisionTM二步法检测25例皮内痣、45例恶性黑素瘤中β联蛋白、淋巴样增强因子1的表达情况.结果β联蛋白在恶性黑素瘤中异常表达率为73%,皮内痣为36%,两组差异有统计学意义;淋巴样增强因子:1在恶性黑素瘤中阳性表达率为62.2%,皮内痣组为0,两组差异有统计学意义.肿瘤组织中淋巴样增强因子1高表达率与淋巴结转移、TNM分期密切相关(P＜0.05),而β联蛋白异常表达率与淋巴结转移及TNM分期无明显关系;β联蛋白异常表达与淋巴样增强因子1高表达之间存在正相关(P＜0.05).结论β联蛋白、淋巴样增强因子1异常表达可能与恶性黑素瘤发病相关.
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