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Detection of Serum Anti-tyrosinase Antibodies and sICAM-1 in Vitiligo Patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 10
- DOI:
- 10.3760/j.issn:0412-4030.2005.10.005
- Key Word:
- 白癜风;抗酪氨酸酶抗体;抗黑素细胞抗体;胞间黏附分子1
Abstract： 目的探讨白癜风患者血清中抗酪氨酸酶IgG、IgM抗体滴度和可溶性细胞间黏附分子1(sICAM-1)水平与疾病活动程度的关系和临床意义.方法抗酪氨酸酶IgG、IgM抗体和sICAM-1检测采用酶联免疫吸附试验(ELISA)方法.结果①白癜风患者血清中抗酪氨酸酶IgG抗体平均滴度为0.316,显著高于正常人对照组0.082(P＜0.001);白癜风患者血清中抗酪氨酸酶IgM抗体平均滴度为0.238,显著高于正常人对照组0.065(P＜0.001).②白癜风患者进展期血清抗酪氨酸酶IgG、IgM抗体滴度明显高于稳定期(P均＜0.001),泛发型明显高于局限型(P均＜0.001).③抗酪氨酸酶IgG、IgM抗体滴度与抗黑素细胞IgG抗体阳性及IgM抗体阳性均呈正相关(P均＜0.001).④白癜风患者血清sICAM-1平均水平为697.40 ng/mL,显著高于正常人对照组602.40ng/ml(P＜0.001);进展期高于稳定期(P＜0.001);泛发型高于局限型(P＜0.001);稳定期和局限型白癜风患者血清中sICAM-1水平与正常人对照组差异无统计学意义(P均＞0.05).结论白癜风患者血清中抗酪氨酸酶IgG、IgM抗体和sICAM-1与疾病活动性和严重程度相关.
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