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Effects of Acitretin on Angiogenesis induced by Vascular Endothelial Growth Factor (VEGF) in Patients with Psoriasis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:0412-4030.2005.09.003
- Key Word:
- 阿维A;银屑病;内皮生长因子;新生血管化,病理性;微血管密度
Abstract： 目的研究阿维A对血管内皮生长因子(VEGF)促银屑病血管生成的调节作用,探讨阿维A治疗银屑病的机制.方法免疫组化法检测32例银屑病患者经阿维A治疗前后皮损的微血管密度和VEGF蛋白的表达情况.应用双抗体夹心酶联免疫吸附法(ELISA)检测32例银屑病患者经阿维A治疗前后外周血清中VEGF水平.结果①银屑病患者经阿维A治疗前皮损VEGF蛋白的表达及微血管密度值显著高于治疗后(P<0.05)和正常人对照组(P<0.001).②银屑病患者阿维A治疗前的血清VEGF水平高于治疗后(P<0.001)及正常人对照组(P<0.001).结论 VEGF在银屑病新生血管生成中起重要作用.阿维A可能通过抗新生血管生成的作用来治疗银屑病.
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