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Clinical Features of Chronic Urticaria in Patients with Positive and Negative Autologous Serum Skin Test
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:0412-4030.2005.06.005
- Key Word:
- 荨麻疹;皮内试验;自身免疫疾病
Abstract： 目的探讨自体血清皮肤试验阳性的慢性荨麻疹患者的临床特点.方法从82例慢性荨麻疹患者中筛选出29例自体血清皮肤试验阳性患者,对其症状体征及病史等进行分析,并用放免法测定其血清中的抗甲状腺球蛋白抗体(TG-AB)和抗甲状腺微粒体抗体(TM-AB),与自体血清皮肤试验阴性的慢性荨麻疹患者进行对比.结果自体血清皮肤试验阳性与阴性的慢性荨麻疹患者在年龄分布、病程上差异无统计学意义(P＞0.05).两组患者症状体征评分比较,自体血清皮肤试验阳性患者皮疹发作时风团较大(P＜0.05),数量较多(P＜0.01),每次发作持续时间较长(P＜0.05),瘙痒更剧烈(P＜0.05);但风团外观较红,隆起不明显(P＜0.01);而两组患者的皮疹发作频次差异无统计学意义(P＞0.05).自体血清皮肤试验阳性的慢性荨麻疹患者伴发血管神经性水肿及系统症状的比例较高,伴随其他自身免疫相关疾病和甲状腺抗体阳性的比例也明显高于自体血清皮肤试验阴性患者(P＜0.05).结论自体血清皮肤试验阳性的慢性荨麻疹多表现为较严重的慢性荨麻疹.
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