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Peripheral Blood Dendritic Cell Subsets in Patients with Condyloma Acuminata
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0412-4030.2005.05.006
- Key Word:
- 尖锐湿疣;树突细胞
Abstract： 目的检测尖锐湿疣患者外周血树突细胞(DC)亚群并探讨其意义.方法采用免疫荧光三标记流式细胞仪检测25例尖锐湿疣患者外周血DC亚群(DC1/CD11c+和DC2/CD123+),并以26例正常人作为对照.结果尖锐湿疣患者外周血CD123+DC百分数为(0.63±0.34)%比对照组(0.41±0.17)%明显增高(P＜0.01).长病程组及复发患者CD123+DC增高明显(均为P＜0.01),而短病程组及初发患者则无明显改变(均为P＞0.05).尖锐湿疣患者组CD11c+DC百分数(1.40%±0.44%)与对照组(1.57%±0.78%)相比差异无统计学意义(P＞0.05).结论尖锐湿疣患者外周血DC2亚群占优势,导致向Th2样免疫反应偏移,此可能与尖锐湿疣的复发和病程的长短有关.
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