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Serum Levels of Hepatocyte Growth Factor and Granulocyte Macrophage-Colony Stimulating Factor in Patients with Psoriasis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:0412-4030.2005.03.005
- Key Word:
- 银屑病;肝细胞生长因子;粒细胞巨噬细胞集落刺激因子
Abstract： 目的探讨肝细胞生长因子(HGF)和粒细胞-巨噬细胞集落刺激因子(GM-CSE)与银屑病的关系.方法采用双抗体夹心酶联免疫吸附试验(ELISA)检测寻常性银屑病患者和正常人血清中HGF和GM-CSF水平.结果进行期寻常性银屑病患者血清中HGF水平明显高于静止期及正常人对照(P＜0.01),而静止期患者血清中HGF水平与正常人对照比较差异无统计学意义(P＞0.05);进行期银屑病患者血清中GM-CSF水平明显高于正常人对照及静止期(P＜0.01),静止期患者血清中GM-CSF水平亦高于正常人对照(P＜0.05);进行期泛发性与局限性皮损患者之间血清HGF及GM-CSF水平差异均无统计学意义;患者血清HGF和GM-CSF水平与PASI计分均呈正相关(分别为r=0.38和r=0.30,P＜0.002和P＜0.02).结论寻常性银屑病患者外周血循环HGF和GM-CSF水平明显增高,HGF和GM-CSF可能参与银屑病发病.
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