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The Association of HLA-DQB1 Alleles and Generalized Pustular Psoriasis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:0412-4030.2005.03.001
- Key Word:
- 银屑病;基因,MHCⅡ类
Abstract： 目的探讨山东汉族人泛发性脓疱性银屑病(GPP)与HLA-DQB1等位基因的相关性.方法运用聚合酶链反应-序列特异性引物(PCR-SSP)法,对38例山东汉族人GPP与94例健康对照进行HLA-DQB1等位基因分型.结果 GPP患者组HLA-DQB1*0201、0603基因频率较对照组显著升高(OR=8.10,Pc=0.005;OR=5.06,Pc=0.013),而HLA-DQB1*0604基因频率较对照组明显降低(OR=0.08,Pc=0.039).原有寻常性银屑病病史的GPP与HLA-DQB1*0201、0603强相关(OR=32.31,Pc=0.005;OR=12.42,Pc=0.005);而原无寻常性银屑病病史的GPP与HLA-DQB1*0602相关(OR=5.60,Pc=0.039).结论山东汉族GPP与HLA-DQB1*0201、0603等位基因高度关联,原有寻常性银屑病病史的GPP与原无寻常性银屑病病史的GPP具有遗传异质性.
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