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Preliminary Study on Flare-Prediction in Patients with Systemic Lupus Erythematosus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0412-4030.2005.01.006
- Key Word:
- 红斑狼疮,系统性;复发;预测
Abstract： 目的探讨常用实验室检查和症状以及血清可溶性白介素2受体(sIL-2R)在预测系统性红斑狼疮(SLE)复发中的价值.方法采用SLE疾病活动指数(SLEDAI)作为病情判定标准,对106例SLE门诊患者进行前瞻性随访,要求患者复诊间隔不超过3个月并随访了6～18个月,每次随访时均按照研究方案记录其实验室检查、临床症状和治疗措施,根据各指标在复发前出现异常的频率和时间综合考察其预测复发的价值.结果106例患者中有67例的病情处于稳定期,符合进行前瞻性观察病情复发的要求,共观察到29例患者的31次复发,复发率为0.44/人·年.综合预测能力最高的指标是抗ds-DNA抗体,其次为补体系统、sIL-2R、血沉、血常规、尿常规、疲乏感、黏膜溃疡、新发皮疹和脱发.C3比C4和CH50能更好地预测SLE复发.结论SLE的复发是可以预测的.早期干预有助于患者避免病情复发.
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