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Association of the E-selectin polymorphism with Systemic Lupus Erythematosus in the Ethnic Zhuang population from Guangxi Province
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0412-4030.2005.01.005
- Key Word:
- 红斑狼疮,系统性;E选择素;多态性,限制性片段长度
Abstract： 目的探讨E选择素基因第2外显子G98T和第4外显子A561C多态性在广西壮族人群中的分布及其与系统性红斑狼疮(SLE)的相关性.方法用聚合酶链反应-限制性片段长度多态性(PCRRFLP)技术检测82例系统性红斑狼疮患者和95例正常对照者E选择素基因型.结果E选择素第2外显子基因型GG、GT、TT频率在SLE组和对照组分别为86.6%、12.2%、1.2%和90.5%、8.4%、1.1%;E选择素第4外显子基因型AA、AC、CC频率在SLE组和对照组分别为81.7%、15.9%、2.4%和92.6%、7.4%、0.0%.E选择素第4外显子基因型频率和等位基因频率在SLE组和对照组比较差异均有统计学意义(P＜0.05).基因型频率的相对风险分析发现,AC+CC基因型患SLE的风险是AA基因型2.81倍(OR=2.81,95%CI为1.087～7.290).结论E选择素A56lC基因多态性与广西壮族人群SLE的发病有相关性,C等位基因可能是SLE的易感基因.
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