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Expression of Inducible Co-Stimulator on T lymphocytes in Peripheral Blood from the Patients with Systemic Lupus Erythematosus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0412-4030.2005.01.004
- Key Word:
- 红斑狼疮,系统性;可诱导共刺激分子;T淋巴细胞;抗原,CD28
Abstract： 目的探讨可诱导共刺激分子(ICOS)在系统性红斑狼疮(SLE)患者外周血T淋巴细胞的表达.方法应用双色荧光抗体染色技术经流式细胞仪检测了33例SLE患者和16例正常人对照者外周血中T淋巴细胞表面ICOS的自然表达水平,同时收集SLE患者的实验室检查指标,并用SLE疾病活动指数(SLEDAI)来判定SLE患者疾病活动程度,比较分析不同组别SLE患者ICOS表达水平与SLEDAI的相关性.结果活动期SLE组T淋巴细胞ICOS表达水平明显高于正常人对照组(P＜0.01)和非活动期SLE组(P＜0.01),非活动期SLE组与正常人对照组T淋巴细胞ICOS表达水平则差异无统计学意义(P＞0.05).活动期组与非活动期组SLE患者T淋巴细胞ICOS表达水平均与SLEDAI呈显著正相关(r=0.71,P=0.001、r=0.56,P=0.03).结论活动期SLE患者T淋巴细胞ICOS表达增高,ICOS可能与SLE的发病机制有关.
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