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Association of HLA-A Alleles with Systemic Lupus Erythematosus

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DERMATOLOGY
Issue:
1
DOI:
10.3760/j.issn:0412-4030.2005.01.002
Key Word:
红斑狼疮,系统性;基因,MHC Ⅰ类;聚合酶链反应-序列特异性引物

Abstract: 目的探讨系统性红斑狼疮(SLE)的发生与HLA-A等位基因间的关系.方法应用聚合酶链反应-序列特异性引物(PCR-SSP)的方法,对106例SLE患者和122例健康人进行HLA-A等位基因的检测.结果共发现19种等位基因,SLE患者中检出18种,对照组中检出15种.其中A*11等位基因与SLE呈强正相关(RR=2.4380,EF=0.1502,X2=12.2440,P=0.0005,Pc=0.0095);A*01和A*24等位基因尽管P值均<0.05(分别为0.0498和0.0124),但Pc值都>0.05(分别为0.9462和0.2356).结论A*11可能是云南汉族SLE的易感等位基因或与易感基因相连锁.

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