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The Study of ERK Pathway Related Protein Expression in Malignant Melanoma and Ordinary Nevi
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:0412-4030.2004.09.002
- Key Word:
- 黑色素瘤;痣;有丝分裂素激活蛋白激酶类;细胞周期蛋白D1
Abstract： 目的探讨恶性黑素瘤(MM)和普通痣细胞痣细胞外信号调节激酶(ERK)途径相关蛋白ERK1和ERK2以及细胞周期素D1(Cyclin D1)蛋白的表达情况,分析这3种蛋白与MM的临床病理关系.方法采用免疫组化SP法对30例MM和13例普通痣细胞痣中ERK1、ERK2和Cyclin D1蛋白的表达进行检测,并进行临床病理相关性分析.结果ERK1、ERK2和Cyclin D1在MM组织中表达较普通痣细胞痣组织明显升高(P＜0.01),ERK1、ERK2和Cyclin D1与MM的Clark分级和Breslow厚度无明显相关性,ERK1和ERK2与Cyclin D1在MM组织中表达显著相关.结论MM中ERK途径得到了过度激活,并可能促使Cyclin D1表达增加,因此它们在MM的发病机制中可能起到一定作用,而它们在普通痣细胞中仅在A型痣细胞表达增加.
- [1]C M, Balch,A C, Buzaid,M B, Atkins,etc.A new American Joint Committee on Cancer staging system for cutaneous melanoma.[J].2000,88(6).
- [2]Helen, Davies,Graham R, Bignell,Charles, Cox,etc.Mutations of the BRAF gene in human cancer.[J].2002,417(6892).