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Clinical Features and CD4+/CD8+ T Lymphocytes in HIV/AIDS Patients with Oropharyngeal Candidiasis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0412-4030.2004.05.003
- Key Word:
- HIV感染;获得性免疫缺陷综合征;念珠菌病,口腔
Abstract： 目的研究HIV/AIDS患者的口咽部念珠菌病的发病特点,CD4计数、CD8计数、CD4+/CD8+比值的分布特点,以及抗真菌治疗的特点.方法观察20例合并口咽部念珠菌病的HIV/AIDS患者和对照组口腔病损情况,病损部行真菌镜检和真菌培养,外周血流式细胞仪检测CD4+、CD8计数.研究组和对照组伊曲康唑治疗第1周、第2周、疗程结束时、停药后两周真菌学疗效比较.结果 19例为白念珠菌感染,1例为近平滑念珠菌感染.20例艾滋病患者可见舌部感染6例,口腔侧壁感染14例.CD4+、CD8计数和CD4+/CD8+比值分别在119.40±127.43、652.50±338.57和0.163±0.130范围.伊曲康唑治疗HIV/AIDS组第1周、第2周、疗程结束时、停药后两周真菌清除率分别为16.67%、50.00%、61.11%、66.67%.结论 HIV/AIDS患者口咽部念珠菌感染的最常见致病菌是白念珠菌,最常见靶部位是舌和口腔侧壁.HIV/AIDS患者的口咽部念珠菌病抗真菌疗效与免疫状态有关.
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