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Gene Mutation of RANTES and CCR5 in Systemic Lupus Erythematosus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0412-4030.2004.01.007
- Key Word:
- 多态性,单核苷酸;基因频率;RANTES;红斑狼疮,系统性;受体,CCR5
Abstract： 目的探讨RANTES SNP及其受体CCR5△32突变之间交互作用对SLE发病的影响.方法收集146例确诊的SLE患者和159例正常人对照.通过PCR-RFLP方法检测研究对象RANTES启动区SNP及其受体CCR5△32突变频率.结果RANTES-403G/G、-28C/C和CCR5/CCR5同时出现的频率在病例组和对照组中分别为72.6%,58.5%(P＜0.01,OR=1 88).单体型Ⅲ(RANTES-403A,-28C)在两组中的分布差异有显著性(11.5%比16.5%,P＜0.05).病例组单体型Ⅳ(RANTES-403A,-28G)实际频率0.9%高于理论频率0.3%(P＜0.05).有肾损害组RANTES-403位点突变等位基因A频率低于无肾损害组和对照组(1.49%比15.62%,1.49%比17.9%,均P＜0.05).RANTES-28位点突变等位基因G、突变等位基因CCR5△32频率在3组间分布差异无显著性.结论RANTES两个SNPs存在着连锁不平衡,RATNES二位点SNP及CCR5基因之间存在交互作用,同时携带RANTES-403 G/G,-28 C/C,CCR5/CCR5基因型的个体可能更易患SLE.RANTES-403位点可能与SLE肾损害有关.
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