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Clinical Features and CSF Changes of SLE Patients with Central Nerve System Involvement
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0412-4030.2004.01.003
- Key Word:
- 红斑狼疮,系统性;中枢神经系统疾病;实验室技术和方法
Abstract： 目的总结系统性红斑狼疮(SLE)患者中枢神经系统损害(CNS-SLE)的临床表现,观察脑脊液(CSF)的变化,探讨CSF在SLE脑病诊断中的意义.方法收集住院确诊的CNS-SLE患者120例,记录临床表现、CSF压力、蛋白定量、糖定量、氯化物、细胞数、血糖等指标,分析临床表现及CSF检测各指标的变化.结果临床表现中以头痛最为常见占38.3%,以后依次为意识障碍、抽搐及癫痫发作、精神病样反应、呕吐、偏瘫、情感异常、烦躁不安、记忆力下降、言语不清,构音困难者占4.16%.磁共振成像(MRI)检查阳性率60.0%,而计算机断层扫描(CT)为33.3%,前者高于后者(P＜0.05).CSF检查表现平均CSF压力(1.85±0.80)kPa,蛋白定量(811.4±708.6)mg/L,细胞数(88.6±448.3)×106/L,而糖定量及糖/血糖比值接近正常范围.结论CNS-SLE临床表现多样化,MRI检查阳性率高于CT检查.CSF改变中以压力升高、蛋白定量升高、细胞计数增加为突出.
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