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Enhanced Expression of Platelet-derived Growth Factor Receptor Proteins in Keloids
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:0412-4030.2003.12.005
- Key Word:
- 瘢痕疙瘩;受体,血小板源生长因子;成纤维细胞
Abstract： 目的探讨血小板衍化生长因子受体(PDGFR)-α和-β在瘢痕疙瘩组织和瘢痕疙瘩来源成纤维细胞中的表达及其在瘢痕疙瘩发病中的作用.方法应用免疫组化法检测15份瘢痕疙瘩和10份正常人皮肤标本PDGFR-α和-β蛋白的分布.体外原代培养成纤维细胞和蛋白质印迹法检测PDGFR蛋白的表达.结果在瘢痕疙瘩组织中PDGFR-β表达明显增高,而PDGFR-α在瘢痕疙瘩中的表达似与瘢痕疙瘩的临床生长状态有关.在边缘充血、浸润生长明显的皮损,PDGFR-α呈强烈表达;而在边缘稳定、无明显浸润态势之皮损,PDGFR-α呈低表达.体外培养的成纤维细胞中,PDGFR-α比PDGFR-β表达更为丰富.结论两种PDGFR的表达增高导致瘢痕疙瘩成纤维细胞对PDGF敏感性提高,决定了PDGF在瘢痕疙瘩发病机制中的作用.
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