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The Levels of Plasma Insulin and Erythrocyte Insulin Receptors in Children with Acanthosis Nigricans Associated with Obesity
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:0412-4030.2003.11.005
- Key Word:
- 肥胖症;儿童;棘皮症,黑;胰岛素;受体,胰岛素
Abstract： 目的探讨胰岛素抵抗在肥胖儿童良性黑棘皮病发病中的作用及其与胰岛素受体数量的关系.方法检测17例良性黑棘皮病肥胖儿童、16例单纯肥胖儿童及15例正常儿童对照的空腹血浆胰岛素及红细胞胰岛素受体水平.结果肥胖儿童良性黑棘皮病组空腹胰岛素水平(59.78±13.13 mIU/L)明显高于单纯肥胖组(20.96±3.44 mIU/L)和正常儿童对照组(11.34±2.62 mIU/L)(P＜0.01),而红细胞胰岛素高、低亲和力受体数量(74.44±8.43,854.73±87.96)却明显低于单纯肥胖组(120.21±16.45,2594.92±118.32)和正常儿童对照组(307.81±17.58,4 074.90±263.59)(P＜0.01).结论胰岛素受体数量降低导致胰岛素抵抗可能是肥胖儿童良性黑棘皮病的病因之一.
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