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Study on the Correlation Between DNase Ⅰ and G-actin of the Blood and Urine in SLE Patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:0412-4030.2003.11.004
- Key Word:
- 红斑狼疮,系统性;脱氧核糖核酸酶Ⅰ;肌动蛋白类
Abstract： 目的探讨系统性红斑狼疮(SLE)患者血和尿中DNaseⅠ活性与肌动蛋白浓度的相关性.方法应用DNA-甲基绿比色法和ELISA间接竞争法检测65例SLE患者和30例正常人对照血、尿中的DNaseⅠ活性和肌动蛋白浓度,分析其相关关系.结果SLE组患者血清、尿DNaseⅠ活性均低于对照组(P＜0.01),病情活动期组两者亦均低于缓解期组(P＜0.01);肾损害组血清DNaseⅠ活性与非肾损害组比较,差异无显著性,而尿DNaseⅠ活性却降低(P＜0.01);SLE组血浆肌动蛋白浓度高于对照组(P＜0.05),但尿肌动蛋白浓度两组间差异无显著性;活动期患者血浆肌动蛋白浓度高于缓解期(P＜0.01),但尿肌动蛋白浓度两组间差异无显著性;肾损害组血浆肌动蛋白浓度与非肾损害组比较,差异无显著性;但前者尿肌动蛋白浓度却高于后者(P＜0.05).SLE患者血浆肌动蛋白浓度与DNaseⅠ活性之间呈负相关(r=-0.35,P＜0.05),而尿肌动蛋白浓度与DNaseⅠ活性之间无相关性(r=-0.23,P＞0.05).结论SLE患者血中DNaseⅠ活性与肌动蛋白浓度之间呈负相关,提示血中肌动蛋白浓度的增高可能是DNaseⅠ活性降低的原因之一.
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