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The Association Between Epstein-Barr Virus and Systemic Lupus Erythematosus (SLE)
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:0412-4030.2003.07.004
- Key Word:
- 红斑狼疮,系统性;疱疹病毒4型,人
Abstract： 目的探讨Epstein-Barr病毒(EBV)感染在系统性红斑狼疮(SLE)病因学中的作用以及EBV活动性感染与疾病活动期的关系.方法PCR技术检测85例SLE患者和43例正常人外周血单一核细胞中EBV DNA,采用巢式PCR(Nested-PCR)技术检测EBV DNA阳性标本EBV增殖期基因BZLF1mRNA的表达,ELISA法检测血清EBV特异性IgM抗体.结果SLE患者组EBV DNA阳性率明显高于对照组(P＜0.05),EBV即刻早期基因BZLF1 mRNA的表达在SLE患者组与对照组中阳性率差异无显著性(P＞0.05),ELISA法检测血清EBV特异性IgM抗体,SLE患者组阳性率高于对照组(P＜0.05).结论SLE患者EBV DNA阳性率高于正常对照组,部分SLE患者存在EBV活动性感染,EBV感染可能与SLE的发生发展有关.
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