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Expression of Vascular Endothelial Growth Factor Receptor in the Lesions of Patients with Psoriasis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:0412-4030.2003.07.001
- Key Word:
- 银屑病;受体,生长因子;新生血管化,病理性
Abstract： 目的探讨血管内皮生长因子受体(FLT-1与KDR)在银屑病皮损中的表达及意义.方法采用免疫组化法检测银屑病患者皮损中FLT-1与KDR的表达与分布特征,同时检测皮损中的微血管密度(MVD).结果在表皮组织中,FLT-1与KDR在患者组与正常人对照组中均有表达,且表达强度差异无显著性(P＞0.05);正常人对照组中,FLT-1、KDR均匀表达于表皮全层,而患者组FLT-1、KDR在颗粒层表达最强.真皮组织中,FLT-1、KDR主要表达在真皮乳头微血管上,且患者组真皮乳头微血管上的表达程度要明显高于正常人对照组(P＜0.01).患者组皮损真皮乳头血管MVD明显高于正常人对照组(P＜0.01).真皮乳头微血管FLT-1、KDR阳性表达组的MVD明显大于阴性表达组的MVD(P＜0.01).FLT-1、KDR与MVD三者之间任何两者均存在正相关关系(P＜0.01).结论FLT-1、KDR在表皮角质形成细胞上有表达,其分布在银屑病皮损中发生了变化.真皮乳头微血管上FLT-1、KDR表达的异常增高与银屑病皮损部真皮乳头血管生成有关.这两种受体在血管生成的过程中可能起作用.FLT-1与KDR之间可能也存在相互促进关系.
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