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A Case Report of Lymphomatoid Papulosis Followed By Mycosis Fungoides: Derived from a Common T Cell Clone
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:0412-4030.2003.06.001
- Key Word:
- 淋巴瘤样丘疹病;淋巴瘤,T细胞;T淋巴细胞;免疫表型分型
Abstract： 目的报道一例淋巴瘤样丘疹病(LyP)继发蕈样肉芽肿(MF),随访27年,并检测其克隆性是否与疾病相关.方法比较不同时期的皮肤组织病理和免疫表型特点,同时应用聚合酶链反应(PCR)和Southern印迹杂交法,检测皮损组织和外周血标本的T细胞受体基因重排.结果此例在不同时期各具临床病理学特征,增生的淋巴细胞为成熟的Th细胞,且示共同T细胞克隆.结论LyP继发MF示相同T细胞克隆,克隆性T细胞与疾病的生物行为无关.
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