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Study on Chemokines and Their Receptors in the Patients with Condyloma Acuminatum
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0412-4030.2003.05.002
- Key Word:
- 尖锐湿疣;趋化因子类;受体,趋化因子
Abstract： 目的研究尖锐湿疣(CA)患者血清趋化性细胞因子及其受体表达的变化在发病机理中的作用.方法采用酶联免疫吸附试验检测30例CA患者及正常人血清中白介素8(IL-8)、γ干扰素诱导蛋白10(IP-10)、单核细胞趋化蛋白1(MCP-1)、巨噬细胞炎性蛋白1α(MIP-1α)、活化后可调节的、正常T细胞表达和分泌的因子(RANTES)及巨噬细胞来源的趋化性细胞因子(MDC)等水平变化.同时用流式细胞仪分析20例CA患者外周血CD3+T淋巴细胞表面趋化性细胞因子受体CXCR1、CXCR3、CCR2及CCR5的表达.结果与正常人对照组相比,CA患者血清IP-10和MIP-1α水平显著升高(P＜0.02和P＜0.05),外周血CXCR1+T细胞百分率显著增加(P＜0.05).结论CA患者血清IP-10和MIP-1α水平及外周血CXCR1+T细胞百分率增高,并与疾病的复发和病程的长短有关.IP-10和MIP-1α在机体非特异性抗病毒免疫应答中起着重要作用.
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