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Cytokine Gene Expression on Fibroblasts from Psoriatic Uninvolved Skin
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:0412-4030.2003.03.005
- Key Word:
- 银屑病;成纤维细胞;细胞活素类;eDNA微阵列技术
Abstract： 目的探讨成纤维细胞分泌的细胞因子在银屑病发病中的作用.方法分别取寻常性银屑病患者非皮损区及正常人皮肤的成纤维细胞进行培养,并建立体外皮肤模型.提取其中的成纤维细胞中的RNA用于cDNA微阵列法检测,比较正常人和银屑病患者非皮损区成纤维细胞在细胞因子基因表达水平的差异.结果在268个细胞因子及其受体相对应的基因中,与正常人组相比,银屑病组的成纤维细胞表达上升的有24个,下降的有3个.结论银屑病患者非皮损区的成纤维细胞较正常人的成纤维细胞具有更强的促表皮细胞增殖作用,其细胞因子的表达提示银屑病患者非皮损区具有潜在的向银屑病皮损发展演变的可能.
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