You Position: Home > Paper
Changes of Circulating Platelet-Derived Growth Factor and Granulocyte Colony-Stimulating Factor in Patients with Psoriasis Vulgaris
( views:173, downloads:9 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:0412-4030.2003.03.004
- Key Word:
- 银屑病;血小板源生长因子;粒细胞集落刺激因子
Abstract： 目的探讨血小板源生长因子(PDGF)和粒细胞集落刺激因子(G-CSF)与寻常性银屑病的关系.方法采用双抗体夹心ABC-ELISA法检测血清中PDGF及G-CSF水平.结果寻常性银屑病患者血清中PDGF水平明显高于正常人对照(P＜0.001),进行期患者血清中PDGF水平增高较静止期更明显(P＜0,001);进行期寻常性银屑病患者血清G-CSF水平明显高于静止期(P＜0.001)及正常人对照(P＜0.01);寻常性银屑病患者血清PDGF和G-CSF水平与PASI计分均呈正相关(分别为r=0.38和r=0.28,P＜0.005和P＜0.05);外周血中性粒细胞计数与G-CSF水平呈正相关(r=0.58,P＜0.001),与PDGF无相关关系.结论寻常性银屑病患者存在循环PDGF和G-CSF水平明显改变,PDGF和G-CSF产生增加与寻常性银屑病的发病机理可能有关.
- [1]黄熙,马圣清,涂平.血小板衍生生长因子受体在银屑病皮损的表达[J].2000,(2).
- [2]T, Fredriksson,U, Pettersson.Severe psoriasis--oral therapy with a new retinoid.[J].1978,157.
- [3]Thierry Vial,Jacques Descotes.Clinical Toxicity of Cytokines Used As Haemopoietic Growth Factors[J].1995,13(6).
- [4]J F, Krane,D P, Murphy,A B, Gottlieb,etc.Increased dermal expression of platelet-derived growth factor receptors in growth-activated skin wounds and psoriasis.[J].1991,96(6).
- [5]Ansel J C,Tiesman J P,Olerud J E,etc.Human keratinocytes are a major source of cutaneous platelet-derived growth factor.[J].1993.
- [6]D'Auria L,Carducci M,Mussi A,etc.Spontaneous release of leukemia inhibitory factor and oncostatin-M is increased in supernatants of short-term organ cultures from lesional psoriatic skin.[J].1998,290(1).