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Expression of TNF alpha Receptor p75 in Skin and Sera of Patients with Psoriasis Vulgaris
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:0412-4030.2003.03.003
- Key Word:
- 银屑病;受体,肿瘤坏死因子
Abstract： 目的探讨肿瘤坏死因子(TNF)α受体75 000(p75)在寻常性银屑病中的作用机制.方法采用免疫组化和ELISA方法对寻常性银屑病患者皮损、皮损周围"正常"皮肤p75表达及其在血清中的含量进行检测.结果正常人皮肤表皮基底细胞散在表达p75;银屑病患者皮损周围"正常"表皮、皮损表皮、真皮内浸润单一核细胞(MNCs)均表达p75;银屑病皮损表皮角质形成细胞p75表达强度与真皮内MNCs数呈显著正相关(r's=0.73,P＜0.05);银屑病患者血清中p75的含量与对照组比较差异有显著性(t=3.98,P＜0.05);银屑病皮损表皮角质形成细胞p75表达强度与其血清中p75含量呈显著正相关(r's=0.62,P＜0.05).结论银屑病患者皮肤和血清中TNFα受体p75的异常上调可能是造成银屑病发生和发展的原因之一.
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