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Serum Level of Interleukin, Tumor Necrosis Factor Alpha and Granulocyte Macrophage-Colony Stimulating Factor in Patients with Vitiligo
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:0412-4030.2003.02.005
- Key Word:
- 白癜风;白细胞介素1;白细胞介素6;白细胞介素8;肿瘤坏死因子;粒细胞巨噬细胞集落刺激因子
Abstract： 目的探讨白介素1β(IL-1β)、白介素6(IL-6)、白介素8(IL-8)、肿瘤坏死因子α(TNF-α)及粒细胞-巨噬细胞集落刺激因子(GM-CSF)等在白癜风患者血清中的变化.方法采用放射免疫分析法测定50例白癜风患者血清细胞因子水平,并用20例正常人作对照.结果局限性、泛发性白癜风患者血清IL-6、GM-CSF水平及泛发性患者血清IL-1β水平均显著高于对照组.节段型患者血清细胞因子水平与对照组比较差异无显著性.局限性、泛发性患者血清GM-CSF水平及泛发性患者血清IL-6水平进展期显著高于稳定期.结论 IL-6和GM-CSF在非节段型白癜风自身免疫机制中可能起一定作用.
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