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Analysis of T-cell receptor γ gene rearrangement for cutaneous T-cell lymphomas

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DERMATOLOGY
Issue:
2
DOI:
10.3760/j.issn:0412-4030.2003.02.004
Key Word:
淋巴瘤,T细胞,皮肤;基因,T细胞受体γ

Abstract: 目的研究皮肤T细胞淋巴瘤(CTCL)早期诊断.方法利用PCR方法,设计TCR Vγ1-8、Vγ9、Jγ1/γ2特异引物,分析24例各类型CTCL,2例可疑CTCL及4例非特异性红皮病患者的33份皮肤和6份淋巴结石蜡标本的TCRγ-GR克隆性,30例炎性皮疹石蜡标本为阴性对照.结果 39份标本中38份示TCRVγ1-8,37份示Vγ9呈MCGR、BCGR或OCGR.尤其是13例早期蕈样肉芽肿,2例可疑CTCL和4例非特异性红皮病均呈TCRγ-GR克隆性扩增带.6例炎性病变标本示TCRγ-GR克隆性,提示他们为"克隆性皮炎",需长期随访.结论用PCR发现早期CTCL的TCRγ-GR克隆性,为诊断提供依据.

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