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Expression of Costimulatory Molecules CD80 and CD86 on Peripheral Blood Lymphocytes in Patients With Systemic Lupus Erythematosus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0412-4030.2003.01.006
- Key Word:
- 红斑狼疮,系统性;抗原,CD80;抗原,CD86
Abstract： 目的探讨系统性红斑狼疮(SLE)患者外周血淋巴细胞(PBLC)CD80和CD86的表达及其意义.方法采用流式细胞仪检测了30例SLE患者PBLC的CD80和CD86抗原,并以25例正常人作为对照结果SLE患者PBLC上CD86的表达显著低于正常对照组(P＜0.05);CD80表达与正常对照组差异无显著性;SLE患者活动期和非活动期、有肾病组和无肾病组的CD80和CD86的表达差异均无显著性:CD80和CD86水平与SLE疾病活动指数(SLEDAI)、ANA滴度、IgG、和C3水平无相关关系.结论SLE患者PBLC上CD86的表达降低,可能与SLE发病机制有关.
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