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Serum Level of Interferon-inducible T Cell Alpha Chemoattractant (I-TAC) in Patients With Systemic Lupus Ervthematosus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0412-4030.2003.01.003
- Key Word:
- 红斑狼疮,系统性;趋化细胞因子类,CXC
Abstract： 目的探讨血清γ干扰素诱导的T细胞α(I-TAC)趋化因子水平与系统性红斑狼疮(SLE)疾病活动的关系及意义.方法采用双抗体夹心ELISA法检测血清I-TAC水平.结果①SLE患者血清I-TAC水平(20.20±6.62 ng/mL)明显高于正常人对照(3.13±0.70 ng/mL),活动期患者(43.96±14.08 ng/mL)高于非活动期患者(2.03±0.46 ng/mL);患者血清I-TAC水平与疾病活动指数(r=0.54,t=4.87,P＜0.001)、血沉(r=0.47,t=3.80,P＜0.001)及ANA对数值(r=0.37,t=3.05,P=0.003)呈正相关,它与补体C3(r＝-0.26,t=2.03,P＜0.05)呈负相关.②肾损组患者(50.22±16.86 ng/mL)血清I-TAC水平明显高于非肾损组患者(7.33±5.11ng/mL).结论I-TAC可能参与SLE的发病机制,血清I-TAC水平可作为监测疾病活动程度和肾脏损害的一个指标.
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