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Cellular Distribution of β -catenin in Epidermal Tumors
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:0412-4030.2002.06.001
- Key Word:
- 癌,鳞状细胞;癌,基底细胞;Bowen病;β-连环蛋白
Abstract： 目的探讨β-连环蛋白在表皮肿瘤中的亚细胞分布及其意义.方法选择Bowen病(BD)、鳞状细胞癌(SCC)和基底细胞癌(BCC)患者各20例,运用免疫组化方法观察肿瘤细胞中β-连环蛋白的表达.结果与正常表皮相比,β-连环蛋白在BCC和SCC肿瘤细胞膜上的表达显著降低,而在SCC和BD肿瘤细胞的胞浆或胞核中的表达显著升高.结论SCC和BD肿瘤细胞的胞浆或胞核区的β-连环蛋白的聚集可能源于β-连环蛋白基因突变,并可能在表皮肿瘤发生中发挥重要作用.
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