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Up- regulation of Expression of Phosphatidylinositol 3- kinase in Psoriatic Lesions
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:0412-4030.2002.02.005
- Key Word:
- 银屑病;1-磷脂酰肌醇3-激酶
Abstract： 目的探讨磷脂酰肌醇3激酶(PI3激酶)与银屑病发病的相关性.方法应用点杂交、原位杂交和免疫组化的方法,分析了12例寻常型银屑病患者皮损区和5例正常人表皮中PI3激酶表达分布特点.结果银屑病皮损中PI3激酶mRNA和蛋白的表达较正常人皮肤明显增强,银屑病患者与正常人皮肤中PI3激酶基因与蛋白的表达一致.结论银屑病皮损中PI3激酶过表达可能与银屑病角质形成细胞的过度增殖相关.
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