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Toxicological study of niuhuang jiedu dripping pill

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Author:
YIN Xiao-fei(Department of Pharmacy,251st Hospital of the People's Liberation Army,Hebei Province,Zhangjiakou 075000,China)
XIE Fei(Department of Pharmacy,251st Hospital of the People's Liberation Army,Hebei Province,Zhangjiakou 075000,China)
WANG Shu-jie(Department of Pharmacy,251st Hospital of the People's Liberation Army,Hebei Province,Zhangjiakou 075000,China)
WANG Wen-sen(Department of Pharmacy,251st Hospital of the People's Liberation Army,Hebei Province,Zhangjiakou 075000,China)
CAI Da-wei(Department of Pharmacy,251st Hospital of the People's Liberation Army,Hebei Province,Zhangjiakou 075000,China)
LIU Jin-hua(Department of Pharmacy,251st Hospital of the People's Liberation Army,Hebei Province,Zhangjiakou 075000,China)
Journal Title:
China Medicine
Issue:
Volume 07, Issue 11, 2012
DOI:
10.3760/cma.j.issn.1673-4777.2012.11.046
Key Word:
Toxicity experiments;Niuhuang jiedu dripping pill;Animals

Abstract: Objective To observe the acute and long-term toxicity of niuhuang jiedu dripping pill.Methods Maximum tolerence dose was determined on mice.Long-term(90 days) toxicity test was studied on rats.Results LD50 of niuhuang jiedu dripping pill given orally was more than 9 g/(kg·d),and there was no obvious long-term toxicity in general conditions,peripheral blood picture,function of liver and kidney and pathological histology in rats.Conclusion Niuhuang jiedu dripping pill is safe.

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