Abstract： Objective To investigate clinical significance of D-dimer level in patients with lupus enteritis.Methods Immunoturbidimetry assay was used to detect the D-dimer level of the systemic lupus erythematosus (SLE) patients who were at the early/active stage of the disease.The 89 SLE patients were classified into two groups:lupus enteritis group and non-gastrointestinal disease group.The 132 health people were as normal control group.Immunoturbidimetry assay was used to detect the D-dimer level of the SLE patients who were at the early/active stage of the disease and control group and analyze the difference of D-dimer level between different groups.Results The mean value of D-dimer of 89 SLE patients was (0.40 ±0.21)mg/L,which significantly higher than that in the normal control group[(0.14 ±0.24)mg/L] (P ＜0.05) ; The mean value of D-dimer in lupus enteritis group was (0.81 ±0.45)mg/L which was significantly higher than that in the normal control group (P ＜0.05).Meanwhile,the mean value of non-gastrointestinal disease group was (0.19± 0.20) mg/L,which was higher than that in the normal control group,which had no statistical significance(P ＞0.05) ; At the same time,the mean value of D-dimer from lupus enteritis group was higher than that from non-gastrointestinal disease group,which had statistical significance (P ＜ 0.01).Thirty-four cases (43.0％) had higher D-dimer value in 79 non-gastrointestinal disease patients,and 26 cases (76.5％) who had higher D-dimer value were vital organ involved such as neuropsychiatric lupus,lupus nephritis,pulmonary hypertension and cardia insufficiency.Conclusions The high D-dimer value is mainly in SLE patients who are sufferring from vital organ involved.The high D-dimer value is also related to gastrointestinal disease such as lupus enteritis.