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A clinical investigation on hemostatic effects of hemocoagulase during laparoscopic cholecystectomy in cirrhotic patients

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Author:
MA Bo(Department of General Surgery,Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
LI Liang(Department of General Surgery,Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
YANG Xu(Department of General Surgery,Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
Journal Title:
China Medicine
Issue:
Volume 07, Issue 11, 2012
DOI:
10.3760/cma.j.issn.1673-4777.2012.11.022
Key Word:
Liver cirrhosis;Cholecystectomy,laparoscopic;Injection hemocoagulase;Hemostasis

Abstract: Objective To explore the hemastatic effect of baquting during laparoscopic cholecystectomy (LC) and its effect on coagulation function in cirrhotic patients (child A class) undergoing LC.Methods Forty cirrhotic patients with cholecystolithiasis were randomly divided into two groups:baquting treatment group(n =20),and etamsvlatum treatment group (n =20).The volume of bleeding during operation and the volume of postoperative 24-hour drainage were recorded in all the patients.Prothrombin time(PT),activated partial thromboplastin time (APTT),thromin time(TT),fibrinogen level and blood platelet counts before and after the surgery were also determined.All the patients were postoperatively followed up for 1 week.Results The volume of bleeding during surgery and the volume of postoperative 24-hour drainage in the baquting treatment group were significantly fewer than the etamsvlatum treatment group(P <0.05).The levels of fibrinogen and blood platelet significandy decreased after the surgery in both the groups compared to preoperation (P<0.05).After the operation the insignificant changes in the coagulation function were observed in baquting treatment group compare to preoperation,whereas PT,APTT,TT in etamsvlatum treatment group were significantly higher after the surgery than those before the surgery (P<0.05).The lower extremity deep venous thrombosis did not occurred within 1 week after the operation in all the patients of both the groups.Conclusions Baquting treatment during LC in cirrhotic patients can reduce the volume of bleeding and the volume of postoperative 24-hour drainage,and does not affect the coagulation function in the patients.Therefore,baquting can be used as a safe and effective hemastatic during operation without increasing the risk of lower extremity deep venous thrombosis in LC patients.

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