Abstract： Objective To explore the correlation of lipoprotein-associated phospholipase A2 (Lp-PLA2),asymmetric dimethyl arginine (ADMA) levels and acute ischemic stroke.Methods There were 151 patients in experimental group and 100 healthy subjects in control group.Level of Lp-PLA2 was detected by enzyme-linked immunosorbent assay (ELISA).Plasma ADMA was detected by high performance liquid chromatography.The size of infarct volume was calculated by cranial magnetic resonance imaging(MRI),and the degree of neurological deficit was evaluated by the U.S.national institutes of health stroke scale(NIHSS scores).Results Total cholesterol (TC),triglyceride (TG),low density lipoprotein-cholesterol(LDL-C) level in acute ischemic stroke plasma group were significantly higher than those in control group [(5.2 ± 1.2) mmol/L vs (3.6± 0.9) mmol/L,(2.0±0.6) mmol/Lvs (1.5 ± 0.4) mmol/L,(3.9±1.2) mmol/L vs (2.3 ± 1.1) mmol/L,respectively].HDL-C was significantly lower than normal but the difference was not statistically significant.Plasma levels of Lp-PLA2 and ADMA showed an increasing trend with the increasing degree of infarction volume (P＜0.05).Plasma levels of Lp-PLA2 and ADMA showed an increasing trend with the increasing degree of neurological deficit (P ＜ 0.05).Conclusions Lp-PLA2 and ADMA levels are significantly increased in patients with acute ischemic stroke.This change is closely related to the volume of cerebral infarction volume and neural injury degree.