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Correlation study of lipoprotein associated phospholipase A2 and asymmetric dimethylarginine with acute ischemic stroke

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Author:
JIN Yan(Department of Laboratory,People' s Hospital Cangzhou,Hebei Province,Cangzhou 061000,China)
ZHANG Chun-he(Department of Laboratory,People' s Hospital Cangzhou,Hebei Province,Cangzhou 061000,China)
WANG Yan-ling(Department of Laboratory,People' s Hospital Cangzhou,Hebei Province,Cangzhou 061000,China)
Journal Title:
China Medicine
Issue:
Volume 07, Issue 11, 2012
DOI:
10.3760/cma.j.issn.1673-4777.2012.11.010
Key Word:
Acute ischemic stroke;Lipoprotein associated phospholipase A2;Asymmetric dimethylarginine;Correlation

Abstract: Objective To explore the correlation of lipoprotein-associated phospholipase A2 (Lp-PLA2),asymmetric dimethyl arginine (ADMA) levels and acute ischemic stroke.Methods There were 151 patients in experimental group and 100 healthy subjects in control group.Level of Lp-PLA2 was detected by enzyme-linked immunosorbent assay (ELISA).Plasma ADMA was detected by high performance liquid chromatography.The size of infarct volume was calculated by cranial magnetic resonance imaging(MRI),and the degree of neurological deficit was evaluated by the U.S.national institutes of health stroke scale(NIHSS scores).Results Total cholesterol (TC),triglyceride (TG),low density lipoprotein-cholesterol(LDL-C) level in acute ischemic stroke plasma group were significantly higher than those in control group [(5.2 ± 1.2) mmol/L vs (3.6± 0.9) mmol/L,(2.0±0.6) mmol/Lvs (1.5 ± 0.4) mmol/L,(3.9±1.2) mmol/L vs (2.3 ± 1.1) mmol/L,respectively].HDL-C was significantly lower than normal but the difference was not statistically significant.Plasma levels of Lp-PLA2 and ADMA showed an increasing trend with the increasing degree of infarction volume (P<0.05).Plasma levels of Lp-PLA2 and ADMA showed an increasing trend with the increasing degree of neurological deficit (P < 0.05).Conclusions Lp-PLA2 and ADMA levels are significantly increased in patients with acute ischemic stroke.This change is closely related to the volume of cerebral infarction volume and neural injury degree.

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