Your Position: Home > Journal List > China Medicine > Paper

Association between primary hypertension and serum vitamin D levels

( views:928, downloads:0 )
ZHAO Yong-qiang(Department of Endocrinology,Anyang District Hospital of Henan Province,Puyang 455000,China)
TIAN De-zeng(Department of Endocrinology,Anyang District Hospital of Henan Province,Puyang 455000,China)
Journal Title:
China Medicine
Volume 07, Issue 11, 2012
Key Word:
Hypertension;25-hydroxyvitamin D3;Parathyroid hormone

Abstract: Objective To investigate the changes of serum vitamin D levels in primary hypertension patients.Methods According to risk factors,56 patients were selected as low risk group; 53 patients were selected as intermediate risk group; 31 patients were selected as high risk group and 33 healthy subjects were selected as normal control group.The 25-hydroxyvitamin D3 was measured with enzyme-linked immunoassay(ELISA).The statistical data was analyzed by SPSS 18.0 software.Results The sex and age of four groups objects were not significantly different.The 25 (OH) D3 of low risk group was (27 ± 6)μg/L; the 25 (OH) D3 of intermediate risk group was (27 ± 5) μg/L.The 25 (OH) D3 of high risk group was (21± 5)μg/L.The 25 (OH) D3 of the healthy subjects was (32 ± 8) μg/L.The 25 (OH) D3 of low risk and high risk and the healthy groups objects were significantly different (P<0.05).With simple regression analysis,the 25 (OH) D3 was positively associated with systolic pressure and diastolic pressure (r =-0.412,-0.377,all P < 0.01),but not significantly associated with the parathyroid hormone,calcium,phosphorous and age.Conclusion There is a high level of hypovitaminosis D in primary hypertension patients.

  • [1]Martins D,Wolf M,Pan D,et al.Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States:data from the Third National Health and Nutrition Examination Survey.Arch Intern Med,2007,167 (11):1159-1165.
  • [2]刘力生,王文,姚崇华.中国高血压防治指南(2009年基层版).中华高血压杂志,2010,18(1):11-30.
  • [3]方永鹏,牛旭东.老年原发性高血压患者动态血压的相关研究.中国医药,2007,2(1):6-7.
  • [4]Scragg RK,Camargo CA Jr,Simpson RU.Relation of serum 25-hydroxyvitamin D to heart rate and cardiac work (from the National Healthand Nutrition Examination Surveys).Am J Cardiol,2010,105(1):122-128.
  • [5]Pfeifer M,Begerow B,Minne HW,et al.Effects of a short-term vitamin D (3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women.J Clin Endocrinol Metab,2001,86(4):1633-1637.
  • [6]Forman JP,Giovannucci E,Holmes MD,et al.Plasma 25-hydroxyvitamin D levels and risk of incident hypertension.Hypertension,2007,49(5):1063-1069.
  • [7]Teresa Johnson,Glenda Avery,Laura Byham-Gray.Vitamin D and Metabolic Syndrome.Top Clin Nutr,2009,24(1):47-54.
  • [8]Wu-Wong JR.Potential for vitamin D receptor agonists in the treatment of cardiovascular disease.Br J Pharmacol,2009,158(2):395-412.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615