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Expression and significance of epidermal growth factor receptor and vascular endothelial growth factors and cyclooxygenase-2 in esophageal carcinoma

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Author:
CHEN Yu(Department of Oncology, Affiliated Hospital of Putian University, Fujian Province, Putian 351100, China)
CHEN Qi-song(Department of Oncology, Affiliated Hospital of Putian University, Fujian Province, Putian 351100, China)
XU Jun-kai(Department of Oncology, Affiliated Hospital of Putian University, Fujian Province, Putian 351100, China)
FANG Jian-chan(Department of Oncology, Affiliated Hospital of Putian University, Fujian Province, Putian 351100, China)
Journal Title:
China Medicine
Issue:
Volume 07, Issue 10, 2012
DOI:
10.3760/cma.j.issn.1673-4777.2012.10.021
Key Word:
Esophageal carcinoma; Epidermal growth factor receptor; Vascular endothelial growth factors; Cyclooxygenase-2

Abstract: Objective To investigate the expression of epidermal growth factor receptor(EGFR),vascular endothelial growth factor(VEGF)and cyclooxygenase-2(COX-2)in esophageal carcinoma(EC)and their relationships with clinicopathologic features. Methods Using immunohistochemical methods,we assessed the expression levels of EGFR,VEGF and COX-2 in 94 surgically resected specimens from patients with EC and 30 normal contiguous esophageal mucosa specimens.We also explored the relationship between the histopathologic features and the expression levels of EGFR,VEGF and COX-2.Results The positive rates of EGFR,VEGF and COX-2 expressions were 13.3%(4/30),13.3%(4/30),3.3%(1/30)in normal mucosa and 69.2%(65/94),73.4%(69/94),84.0%(79/94)in EC respectively.There were significant differences between the two groups (P<0.01). In EC,high EGFR,VEGF and COX-2 expressions had a positive correlation with tumor node metastases classification and lymph node metastasis(P < 0.05).Conclusions EGFR,VEGF and COX-2 are overexpressed in EC.They might participate in tumorigenesis and progression. Over-expression of EGFR,VEGF and COX-2 can be used as a biological marker to evaluate the behavior of EC.

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