Clinical analysis of alteplase treating acute myocardial infarction in elderly patients
- Author:
- No author available
- Journal Title:
- China Medicine
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1673-4777.2012.10.002
- Key Word:
- 急性心肌梗死;阿替普酶;尿激酶;临床疗效;老年患者;Acute myocardial infarction;Alteplase;Urokinase;Clinical effect;Elderly patients
Abstract： Objective To observe the clinical outcome of alteplase treating acute myocardial infarction (AMI)in elderly patients.Methods One hundred and eighty-four cases of elderly patients with acute myocardial infarction were randomly divided into control group and observation group with 92 cases in each group.The two group received routine treatment.The control group was administrated with urokinase,while the observation group was treated with alteplase.Clinical efficacy,clinical symptom remission rate and end point were compared between two groups.Results The total efficiency of control group was 87.0％ and that of observation group was 95.7％,and the difference was statistically significant.The symptoms of chest pain remission rate and recanalization in observation group were higher than those in the control group(P ＜ 0.05); the mean duration of hospitalization in observation group was significantly lower than that in the control group(P ＜ 0.05); the end event rates were lower than those in control group,but there were not statistically significant.Conclusion Aheplase treating with AMI has curative clinical effect and few adverse reactions.
- [1]魏芳,文淑峰,赵皎皎,等.替罗非班对急性心肌梗死择期介入治疗患者血流灌注及心功能的影响[J].2011,(11).
- [2]田才林,刘岳怀.阿替普酶与尿激酶治疗急性心肌梗死患者的疗效[J].2011,(6).
- [3]中华医学会心血管病学分会,中华心血管病杂志编辑委员会,《中国循环杂志》编辑委员会.急性心肌梗死诊断和治疗指南[J].2001,(12).
- [4]Uehara,T.,Naritomi,H.,Toyoda,K.,etc.Carotid duplex ultrasonography can predict outcome of intravenous alteplase therapy for hyperacute stroke[J].2011,20(1).
- [5]Erich, Bluhmki,Angel, Chamorro,Antoni, Dávalos,etc.Stroke treatment with alteplase given 3.0-4.5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial.[J].2009,8(12).
- [6]Sung Soo, Kim,Hong Sang, Choi,Myung Ho, Jeong,etc.Clinical outcomes of acute myocardial infarction with occluded left circumflex artery.[J].2011,57(3).
- [7]Chae SC,Kim JH,Hong TJ,etc.Are patients with angiographically near-normal coronary arteries who present as acute myocardial infarction actually safe?[J].2011,146(2).
- [8]Minematsu K,Mori E,Nakagawara J,etc.Factors predicting outcome in stroke patients treated with 0.6 mg/kg alteplase: evidence from the Japan Alteplase Clinical Trial (J-ACT).[J].2011,20(6).
- [9]Dong-Hui Huang,Hu Zhao,YU Ming,etc.Urokinase Receptor Gene Expression Inhibited by siRNA Cocktails in Co-culture of Spermatogenic Cells with Sertoli Cells from 3-Week-Old Rat[J].2010,(2).