Abstract： Objective To observe the effect of the re-operation after mechanical valve replacement and to analyze dysfunction reason,operation time and operation effect of reoperation.Methods Thirty-three cases with reoperation of valve replacement were chosen from March 2003 to May 2010,including 17 cases of mitral valve replacement,9 aortic valve replacement,2 mitral valve and aortic valve replacement,2 mitral valve replacement and 3 tricuspid valve annuloplasty and 3 tricuspid valve replacement Heart function was compared before and after operation according to the New York Heart Association (NYHA).Results Among 33 cases of reoperation,1 case (3.0％)died and heart function of 32 survival cases improved significantly.The number of preoperative heart function grade Ⅰ,Ⅱ,Ⅲ,Ⅳ was 0,13 (39.4％ ),15 (45.4％)and 5 (15.2％ ).After 6 months,32 patients survived;the number of preoperative heart function grade Ⅰ, Ⅱ,Ⅲ,Ⅳ was 16 (50.0％),12 (37.5％),4 (12.5％ )and 0.The proportion of the patients in grade Ⅰ,Ⅲ,Ⅳ showed statistical difference (P ＜0.05).Conclusion Reoperation is the main therapy method of treating valve dysfunction after mechanical valve replacement;we should pay attention to operation time,operation method and selection of valve type.