Abstract: Objective To compare the efficacy of initially antiviral therapy for chronic hepatitis B with home-made Entecavir dispersible tablets and imported enteeavir tablets and lamivudine.Metbods Totally 168HBeAg-positive patients without receiving any antiviral therapy were selected.Patients were randomly divided into 3 groups:lamivudine group(58 cases),imported entecavir tablets(56 cases) and home-made entecavir dispersible tablets(54 cases),respectively,for 1 year.Results The serum ALT normalization rate,HBeAg negative rate and the HBV DNA negative rate of home-made Entecavir dispersible tablets group in the 12th,24th and 48th week were significantly higher than those of lamivudine group.In the 12th,24th and 48th week ALT normalization,HBeAg and HBV DNA negative conversion rate of home-made entecavir was significantly higher than those of the lamivudine group.There was no significant difference between imported entecavir group and home-made entecavir group.Conclusion Home-made entecavir for the treatment of chronic hepatitis initial antiviral efficacy is significantly higher than lamivudine group but there is no significant difference with imported entecavir.