Your Position: Home > Journal List > China Medicine > Paper

Clinicopathologicaland teatures and treatment of hepatitis B virus associated glomerulonephritis

( views:138, downloads:0 )
XIAO Feng-lin(Department of Nephrology, Navy General Hospital, Beijing 100048, China)
ZHOU Chun-hua(Department of Nephrology, Navy General Hospital, Beijing 100048, China)
Journal Title:
China Medicine
Volume 07, Issue 07, 2012
Key Word:
Glomerulonephritis,hepatitis B virus associated;Hepatitis B;Pathological characters

Abstract: Objective To explore the clinical features and curative effect of Hepatitis B virus associated glomerulonephritis(HBV-GN).Methods The pathology,clinical manifestation of 21 HBV-GN potients diagnosed by renal biopsy were analyzed.HBsAg,anty-HBs,anty-HBc,HBeAg,anti-HBe and urine protein in 24 hours were assayed.HBsAg and HBcAg of nephridial tissue were detected by immunohistochemical method.The treatment of hormone combined of mycophenolate mofetil or leflunomide,or ciclosporin A were used and the therapeulic effect was assessed.Results There were 21 patients diagnosed of HBV-GN.The ratio of male:female was 6:1.The clinical symptom of 8 patients(38.1%) was nephrotic syndrome and HBV-DNA positive rate was 9.5%(2/21).Of 21 cases,8 cases were with membranous glomerulonephrilis,6 cases with mesangial proliferative glomerulonephritis,4 cases with IgA nephropathy and 3 cases with membrane proliferative glomendonephritis.The positive rate of HBsAg and HBcAg in kidney tissues was 71.4%(15/21) and 85.7%(18/21).Of seven patients treated with hormone combined with leflunomide,the condition of 2 cases was complete remission,and others were partial remission.The total effective rate was 85.7%(18/21).Conclusions HBV-GN is more common in male.The most common clinical symptom is nephrotic syndrome,and membranous glomerulonephritis is the most frequent pathological type.Hormone combined leflunomide has some effect in the treatment of HBV-GN.

  • [1]Lin CY.Clinical features and natural coures of HBV-related glomerulopathy in children.Kidney Int Suppl,1991,35:S46-S53.
  • [2]宋新文,邓存良,盛云建,等.外周血单个核细胞对肾小管上皮细胞凋亡影响研究.中国煤炭工业医学杂志,2006,9(3):231-232.
  • [3]中华内科杂志编委会.乙型肝炎病毒相关肾炎座谈会纪要.中华内科杂志,1990,29(9):519-521.
  • [4]王海燕,郑法雷,刘玉春,等.原发性肾小球疾病分型与治疗及诊断标准专题座谈会纪要.中华内科杂志,1993,32(2):131-134.
  • [5]殷海燕,王合群,周雍军,等.86例乙肝相关性肾炎特点分析.中国实用医药,2009,4(4):99-100.
  • [6]European Association for the Study of the Liver.EASL ClinicalPractice Guidelines:management of chronic hepatitis B.J Hepatol,2009,50(2):227-242.
  • [7]崔若兰,袁伟杰.乙型肝炎病毒相关性肾炎的诊治现状.内科理论与实践,2007,2(6):376-379.
  • [8]Zhang Y,Zhou JH,Yin XL,et al.Treatment of hepatitis B virus-assoeiated glomerulonephritis:a meta-analysis.World J Gastroenterol,2010,16(6):770-777.
  • [9]戴玮玮,吴卫锋.恩替卡韦联合霉酚酸酯治疗乙肝病毒相关性肾炎的疗效.中国生化药物杂志,2008,29(6):411-412.
  • [10]向慧,孙剑.来氟米特与霉酚酸酯治疗乙肝病毒相关性肾炎的疗效比较.临床医学工程,2011,18(2):213-215.
  • [11]左淑欣,姚修全.贺普丁联合中药治疗乙肝病毒相关性肾炎3例.中国煤炭工业医学杂志,2002,5(7):740.
  • [12]汤力,陈香美,赵威,等.霉酚酸酯治疗乙肝病毒相关性肾炎的临床研究.北京医学,2005,27(3):166-169.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615